Anle138b

Name: Anle138b
Brand: Tocris Bioscience
SKU: 6861

Tocris Bioscience, part of Bio-Techne | Catalog # 6861

COA / SDS

Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation

Key Product Details

Description:	Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation
Chemical Name:	3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Purity:	≥98% (HPLC)
Molecular Weight:	343.18

View Full Technical Details for Anle138b

Technical Data
Citations

Biological Activity for Anle138b

Anle138b is an oligomeric aggregation inhibitor that inhibits formation of pathological prion protein (PrP^Sc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrP^Sc in brain and spleen, and prolongs survival of prion-infected mice. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.

Technical Data for Anle138b

M. Wt	343.18
Formula	C₁₆H₁₁BrN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	882697-00-9
PubChem ID	44608289
InChi Key	RCQIIBJSUWYYFU-UHFFFAOYSA-N
Smiles	BrC1=CC=CC(=C1)C1=CC(=NN1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Anle138b

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.16	50

Preparing Stock Solutions for Anle138b

The following data is based on the product molecular weight 343.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.83 mL	29.14 mL	58.28 mL
2.5 mM	1.17 mL	5.83 mL	11.66 mL
5 mM	0.58 mL	2.91 mL	5.83 mL
25 mM	0.12 mL	0.58 mL	1.17 mL

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References for Anle138b

References are publications that support the biological activity of the product.

Wagner Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 2013 PMID: 23604588