AP 1867

Name: AP 1867
Brand: Tocris Bioscience
SKU: 6207

Tocris Bioscience, part of Bio-Techne | Catalog # 6207

COA / SDS

Selective binding ligand for FKBP12F36V

Key Product Details

Description:	Selective binding ligand for FKBP12^F36V
Chemical Name:	(1R)-1-[3-(Carboxymethoxy)phenyl]-3-(3,4-dimethoxyphenyl)propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate
Purity:	≥98% (HPLC)
Molecular Weight:	693.79

View Full Technical Details for AP 1867

Technical Data
Citations

Biological Activity for AP 1867

AP 1867 is a selective binding ligand for the single point mutant of FKBP12^F36V (IC₅₀ = 1.8 nM). Functionalized with a carboxylic acid group at the meta-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with the compound's binding ability.

Technical Data for AP 1867

M. Wt	693.79
Formula	C₃₈H₄₇NO₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	195514-23-9
PubChem ID	444590
InChi Key	XCCRAOPQCACRFC-OIFRRMEBSA-N
Smiles	O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(O)=O)=CC=C3)CCC4=CC(OC)=C(OC)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AP 1867

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	69.38	100
	DMSO	69.38	100

Preparing Stock Solutions for AP 1867

The following data is based on the product molecular weight 693.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.41 mL
5 mM	0.29 mL	1.44 mL	2.88 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

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Reconstitution Calculator

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References for AP 1867

References are publications that support the biological activity of the product.

Clackson Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.U.S.A. 1998 PMID: 9724721
Koide A synthetic library of cell-permeable molecules. J.Am.Chem.Soc. 2001 PMID: 11456541