AP 1903

Name: AP 1903
Brand: Tocris Bioscience
SKU: 6130

Tocris Bioscience, part of Bio-Techne | Catalog # 6130

Citations (1)

COA / SDS

Chemical inducer of protein dimerization; active in vivo

Key Product Details

Description:	Chemical inducer of protein dimerization; active in vivo
Chemical Name:	2,2'-[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
Purity:	≥98% (HPLC)
Molecular Weight:	1411.65

View Full Technical Details for AP 1903

Technical Data
Citations

Biological Activity for AP 1903

AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBP^F36V and intracellular domain of Fas receptor with high potency (EC₅₀ = 0.1 nM). Exhibits >50-fold selectivity for FKBP^F36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active in vivo.

Technical Data for AP 1903

M. Wt	1411.65
Formula	C₇₈H₉₈N₄O₂₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	195514-63-7
PubChem ID	16135625
InChi Key	GQLCLPLEEOUJQC-ZTQDTCGGSA-N
Smiles	O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCCNC(COC4=CC=CC([C@H](OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C4)=O)=O)=CC=C3)CCC8=CC(OC)=C(OC)C=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AP 1903

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	141.16	100
	ethanol	141.16	100

Preparing Stock Solutions for AP 1903

The following data is based on the product molecular weight 1411.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.71 mL	3.54 mL	7.08 mL
5 mM	0.14 mL	0.71 mL	1.42 mL
10 mM	0.07 mL	0.35 mL	0.71 mL
50 mM	0.01 mL	0.07 mL	0.14 mL

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References for AP 1903

References are publications that support the biological activity of the product.

Gargett & Brown The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Front.Pharmacol. 2014 PMID: 25389405
Clackson Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.USA. 1998 PMID: 9724721