APY 29

Name: APY 29
Brand: Tocris Bioscience
SKU: 4865

Tocris Bioscience, part of Bio-Techne | Catalog # 4865

Citations (6)

COA / SDS

Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity

Key Product Details

Chemical Name:	N²-1H-Benzimidazol-6-yl-N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Purity:	≥98%

View Full Technical Details for APY 29

Technical Data
Citations

Biological Activity for APY 29

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC₅₀ = 280 nM) and activates IRE1α ribonuclease activity.

Technical Data for APY 29

Formula	C₁₇H₁₆N₈
Storage	Store at -20°C
Purity	≥98%
CAS Number	1216665-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for APY 29

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl

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References for APY 29

References are publications that support the biological activity of the product.

Korennykh et al. The unfolded protein response signals through high-order assembly of Ire1. Nature, 2009;457:687 PMID: 19079236
Wang et al. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol., 2012;8:982 PMID: 23086298

APY 29

Tocris Bioscience, part of Bio-Techne | Catalog # 4865

Key Product Details

Biological Activity for APY 29

Technical Data for APY 29

Solubility for APY 29

Dilution Calculator

Reconstitution Calculator

References for APY 29

Product Documents for APY 29

COA

Certificate of Analysis

SDS

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