Arbidol

Name: Arbidol
Brand: Tocris Bioscience
SKU: 7235

Tocris Bioscience, part of Bio-Techne | Catalog # 7235

COA / SDS

Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral

Key Product Details

Description:	Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
Chemical Name:	Ethyl 6-Bromo-4-((dimethylamino)methyl)-5-hydroxy-1-methyl-2-((phenylthio)methyl)-1H-indole-3-carboxylate hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	513.88

View Full Technical Details for Arbidol

Technical Data
Citations

Biological Activity for Arbidol

Arbidol is a broad spectrum antiviral. Displays activity against a range of respiratory and hepatitis viruses including influenza A, B and C, adenovirus, and hepatitis B and C. Increases stability of influenza viral hemagglutinins (HA) and prevents low-pH HA transition so inhibiting viral fusion. Also inhibits SARS-CoV-2 infection in vitro (IC₅₀ = 4.11 μM).

Compound Libraries for Arbidol

Arbidol is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Arbidol

M. Wt	513.88
Formula	C₂₂H₂₅BrN₂O₃S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	131707-23-8
PubChem ID	9958103
InChi Key	OMZHXQXQJGCSKN-UHFFFAOYSA-N
Smiles	Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Arbidol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	51.39	100
	DMSO	51.39	100

Preparing Stock Solutions for Arbidol

The following data is based on the product molecular weight 513.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.73 mL	19.46 mL
5 mM	0.39 mL	1.95 mL	3.89 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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Reconstitution Calculator

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References for Arbidol

References are publications that support the biological activity of the product.

Wang The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020 PMID: 32373347
Boriskin Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr.Med.Chem. 2008 PMID: 18393857