Argatroban

Name: Argatroban
Brand: Tocris Bioscience
SKU: 1637

Tocris Bioscience, part of Bio-Techne | Catalog # 1637

Citations (3)

COA / SDS

Potent thrombin inhibitor

Key Product Details

Description:	Potent thrombin inhibitor
Chemical Name:	(2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Purity:	≥99% (HPLC)
Molecular Weight:	508.63

View Full Technical Details for Argatroban

Technical Data
Citations

Biological Activity for Argatroban

Argatroban is a potent inhibitor of thrombin mediated fibrinogen cleavage (K_i = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.

This compound is a mixture of 2 diastereomers (approximate ratio 65/35).

Compound Libraries for Argatroban

Argatroban is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Argatroban

M. Wt	508.63
Formula	C₂₃H₃₆N₆O₅S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	74863-84-6
PubChem ID	6604954
InChi Key	CQTDZUSQSTUZDA-UHFFFAOYSA-M
Smiles	O=C(N1[C@@H]([C@@](O)=O)C[C@H](C)CC1)[C@@H](NS(C2=CC=CC3=C2NCC(C)C3)(=O)=O)CCCNC(N)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Argatroban

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.86	100
	1eq. HCl	5.09	10

Preparing Stock Solutions for Argatroban

The following data is based on the product molecular weight 508.63.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.83 mL	19.66 mL
5 mM	0.39 mL	1.97 mL	3.93 mL
10 mM	0.20 mL	0.98 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for Argatroban

References are publications that support the biological activity of the product.

Jang Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 1990 PMID: 2297828
Fitzgerald and Fitzgerald Role of thrombin and thromboxane A₂ in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA
Kikumoto Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 1984 PMID: 6691968