Aripiprazole

Name: Aripiprazole
Brand: Tocris Bioscience
SKU: 5584

Tocris Bioscience, part of Bio-Techne | Catalog # 5584

Citations (12)

COA / SDS

High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist

Key Product Details

Description:	High affinity D₂ and 5-HT_1A receptor partial agonist; also 5-HT_2A antagonist
Chemical Name:	7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Purity:	≥99% (HPLC)
Molecular Weight:	448.39

View Full Technical Details for Aripiprazole

Technical Data
Citations

Biological Activity for Aripiprazole

Aripiprazole is a high affinity dopamine D₂ and 5-HT_1A receptor partial agonist (K_i values are ~1.64 and 5.59 nM respectively). Also 5-HT_2A antagonist (K_i = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.

Compound Libraries for Aripiprazole

Aripiprazole is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Aripiprazole

M. Wt	448.39
Formula	C₂₃H₂₇Cl₂N₃O₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	129722-12-9
PubChem ID	60795
InChi Key	CEUORZQYGODEFX-UHFFFAOYSA-N
Smiles	O=C2CCC1=CC=C(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Aripiprazole

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.84	100

Preparing Stock Solutions for Aripiprazole

The following data is based on the product molecular weight 448.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.15 mL	22.30 mL
5 mM	0.45 mL	2.23 mL	4.46 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References for Aripiprazole

References are publications that support the biological activity of the product.

Shiokawa Usefulness of the DA system-stabilizer aripipr. for reducing morphine-induced emesis. Eur.J.Pharmacol. 2007 PMID: 17678644
Davies Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 PMID: 15592581