ASB 14780

Name: ASB 14780
Brand: Tocris Bioscience
SKU: 6316

Tocris Bioscience, part of Bio-Techne | Catalog # 6316

Citations (3)

COA / SDS

Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable

Key Product Details

Description:	Potent and selective cytosolic phospholipase A₂ alpha (cPLA₂α) inhibitor; active in vivo; orally bioavailable
Chemical Name:	3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt
Purity:	≥98% (HPLC)
Molecular Weight:	582.7

View Full Technical Details for ASB 14780

Technical Data
Citations

Biological Activity for ASB 14780

ASB 14780 is a potent and selective cytosolic phospholipase A₂ alpha (cPLA₂α) inhibitor (IC₅₀ = 20 nM). Selective for cPLA₂α over secreted PLA₂α (sPLA₂α; exhibits no inhibition at 10 μM). Inhibits cPLA₂α-dependent inflammatory responses in vitro in guinea pig and human whole-blood assays. Improves diet-induced liver injury and CCl4-induced hepatic fibrosis in vivo. Orally bioavailable.

Technical Data for ASB 14780

M. Wt	582.7
Formula	C₃₁H₂₇NO₃.C₄H₁₁NO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1069046-00-9
PubChem ID	68519061
InChi Key	MBPXGBINIINSEU-UHFFFAOYSA-N
Smiles	NC(CO)(CO)CO.OC(CCC1=CC=C2N(C3=CC=C(C=C3)OC4=CC=CC=C4)C=C(C2=C1)CCC5=CC=CC=C5)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ASB 14780

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	58.27	100

Preparing Stock Solutions for ASB 14780

The following data is based on the product molecular weight 582.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.72 mL	8.58 mL	17.16 mL
5 mM	0.34 mL	1.72 mL	3.43 mL
10 mM	0.17 mL	0.86 mL	1.72 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

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References for ASB 14780

References are publications that support the biological activity of the product.

Tomoo Design, synthesis, and biological evaluation of 3-(1-aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A₂α. J.Med.Chem. 2014 PMID: 25102418
Kanai ASB14780, an orally active inhibitor of group IVA phospholipase A₂, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease. J.Pharmacol.Exp.Ther. 2016 PMID: 26699145