Phospholipase Inhibitors: Small Molecules and Peptides
Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.
13 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
13 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
Phospholipase Inhibitors: Small Molecules and Peptides
Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.
Phospholipase C inhibitor
| Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione |
| Purity: | ≥98% (HPLC) |
Analog of U 73122 (Cat. No. 1268)
| Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione |
| Purity: | ≥98% (HPLC) |
Phospholipase A2 inhibitor
| Alternate Names: | Arachidonyl trifluoromethyl ketone |
| Chemical Name: | 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one |
Secretory phospholipase A2 (sPLA2) inhibitor
| Chemical Name: | 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone |
| Purity: | ≥95% (HPLC) |
High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor
| Chemical Name: | N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide |
| Purity: | ≥98% (HPLC) |
Phospholipase D inhibitor
| Chemical Name: | N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride |
| Purity: | ≥98% |
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable
| Chemical Name: | 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt |
| Purity: | ≥98% |
Potent inhibitor of PLD1 and PLD2; CNS penetrant
| Chemical Name: | 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide |
| Purity: | ≥98% |
Selective PC-PLC inhibitor
| Chemical Name: | O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate |
| Purity: | ≥98% (HPLC) |
Potent and selective PLD1 inhibitor
| Chemical Name: | N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide |
| Purity: | ≥98% |
Potent and selective PLD2 inhibitor
| Chemical Name: | N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent lp-PLA2 inhibitor
| Chemical Name: | N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide |
| Purity: | ≥98% (HPLC) |
Diacylglycerol lipase inhibitor
| Chemical Name: | O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone |
| Purity: | ≥95% |
