Phospholipase Inhibitors: Small Molecules and Peptides
Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.
12 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
12 results for "Phospholipase Inhibitors Small Molecules and Peptides" in Products
Phospholipase Inhibitors: Small Molecules and Peptides
Secretory phopholipase A2 (PLA2) enzymes cleave an acyl ester bond in the sn-2 position of glycerophospholipids. These extracellular proteins have a high disulfide bond content, low molecular mass (14 kDa), and require mM levels of Ca2+ for catalysis. They play a crucial role in the generation of arachidonates and eicosanoids, and have a number of biological actions including immunological responses, inflammation, cellular proliferation, vasoconstriction, and bronchioconstriction.
Phospholipase C inhibitor
Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione |
Purity: | ≥98% (HPLC) |
Analog of U 73122 (Cat. No. 1268)
Chemical Name: | 1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione |
Purity: | ≥98% (HPLC) |
Phospholipase A2 inhibitor
Alternate Names: | Arachidonyl trifluoromethyl ketone |
Chemical Name: | 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one |
Potent and selective cytosolic phospholipase A2 alpha (cPLA2α) inhibitor; active in vivo; orally bioavailable
Chemical Name: | 3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt |
Purity: | ≥98% (HPLC) |
Phospholipase D inhibitor
Chemical Name: | N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethy]-5-fluoro-1H-indole-2-carboxamide hydrochloride |
Purity: | ≥98% (HPLC) |
High affinity N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor
Chemical Name: | N-(Cyclopropylmethyl)-6-[(3S)-3-hydroxy-1-pyrrolidinyl]-2-[(3S)-3-phenyl-1-piperidinyl]-4-pyrimidinecarboxamide |
Purity: | ≥98% (HPLC) |
Secretory phospholipase A2 (sPLA2) inhibitor
Chemical Name: | 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone |
Purity: | ≥95% (HPLC) |
Potent inhibitor of PLD1 and PLD2; CNS penetrant
Chemical Name: | 4-Bromo-N-[(1S)-2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]-1-methylethyl]benzamide |
Purity: | ≥98% (HPLC) |
Selective PC-PLC inhibitor
Chemical Name: | O-(Octahydro-4,7-methano-1H-inden-5-yl) carbonopotassium dithioate |
Purity: | ≥98% (HPLC) |
Potent and selective PLD2 inhibitor
Chemical Name: | N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide |
Purity: | ≥98% (HPLC) |
Potent lp-PLA2 inhibitor
Chemical Name: | N-[2-(Diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide |
Purity: | ≥98% (HPLC) |
Diacylglycerol lipase inhibitor
Alternate Names: | U 57908 |
Chemical Name: | O,O'-[1,6-Hexanediylbis(iminocarbonyl)]dioxime cyclohexanone |
Purity: | ≥95% (HPLC) |