Ascomycin

Name: Ascomycin
Brand: Tocris Bioscience
SKU: 4210
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4210

(1)

COA / SDS

Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)

Discontinued Product

4210 has been discontinued. View all Protein Ser/Thr Phosphatase Inhibitors products.

Key Product Details

Description:	Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)
Alternative Names:	FK 520,FR 900520
Chemical Name:	(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Molecular Weight:	792.01

View Full Technical Details for Ascomycin

Technical Data
Citations / Reviews (1)

Biological Activity for Ascomycin

Ascomycin is a analog of FK 506 (Cat. No. 3631); binds to FK 506-binding protein 12 (FKBP12) in order to inhibit calcineurin phosphatase activity (IC₅₀ = 49 nM) and activation of nuclear factor of activated T cells (NFAT). Displays antifungal and immunosuppressive activities.

Technical Data for Ascomycin

M. Wt	792.01
Formula	C₄₃H₆₉NO₁₂
Storage	Store at -20°C
CAS Number	104987-12-4
PubChem ID	5282071
InChi Key	ZDQSOHOQTUFQEM-NURRSENYSA-N
Smiles	O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Ascomycin

References are publications that support the biological activity of the product.

Hatanaka FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physicochemical and biological characteristics. J.Antibiot (Tokyo).
Arndt Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology 1999 PMID: 10463165
Revill Genetically engineered analogs of ascomycin for nerve regeneration. J.Pharmacol.Exp.Ther. 2002 PMID: 12183690
Motamedi Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J.Bacteriol. 1996 PMID: 8752344

Ascomycin

Tocris Bioscience, part of Bio-Techne | Catalog # 4210

Key Product Details

Biological Activity for Ascomycin

Technical Data for Ascomycin

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Ascomycin

Product Documents for Ascomycin

COA

Certificate of Analysis

SDS

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