ASP 2535

Name: ASP 2535
Brand: Tocris Bioscience
SKU: 5308

Tocris Bioscience, part of Bio-Techne | Catalog # 5308

Citations (2)

COA / SDS

Potent and selective GlyT1 inhibitor

Key Product Details

Description:	Potent and selective GlyT1 inhibitor
Chemical Name:	4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
Purity:	≥98% (HPLC)
Molecular Weight:	382.42

View Full Technical Details for ASP 2535

Technical Data
Citations

Biological Activity for ASP 2535

ASP 2535 is a potent and selective GlyT1 inhibitor (IC₅₀ = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.

Compound Libraries for ASP 2535

ASP 2535 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ASP 2535

M. Wt	382.42
Formula	C₂₂H₁₈N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	374886-51-8
PubChem ID	9800113
InChi Key	FQGLDGKVKDPVLO-UHFFFAOYSA-N
Smiles	CC(C)C1=NN=C(C4=CN=C(C5=CC=CC=C5)C=C4)N1C3=CC=CC2=NON=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ASP 2535

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.24	100
	ethanol	38.24	100

Preparing Stock Solutions for ASP 2535

The following data is based on the product molecular weight 382.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.07 mL	26.15 mL
5 mM	0.52 mL	2.61 mL	5.23 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for ASP 2535

References are publications that support the biological activity of the product.

Harada A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's diseas Eur.J.Pharmacol. 2012 PMID: 22542656