(+)-MK 801 maleate

Name: (+)-MK 801 maleate
Brand: Tocris Bioscience
SKU: 0924
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 0924

(1)

Citations (92)

COA / SDS

Non-competitive NMDA antagonist; acts at ion channel site

Key Product Details

Description:	Non-competitive NMDA antagonist; acts at ion channel site
Alternative Names:	Dizocilpine
Chemical Name:	(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate
Purity:	≥99% (HPLC)
Molecular Weight:	337.37

View Full Technical Details for (+)-MK 801 maleate

Technical Data
Citations / Reviews (1)

Biological Activity for (+)-MK 801 maleate

(+)-MK 801 maleate is a high affinity (K_i= 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca²⁺ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Compound Libraries for (+)-MK 801 maleate

(+)-MK 801 maleate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (+)-MK 801 maleate

M. Wt	337.37
Formula	C₁₆H₁₅N.C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	77086-22-7
PubChem ID	6420042
InChi Key	QLTXKCWMEZIHBJ-PJGJYSAQSA-N
Smiles	O=C(O)/C=C\C(O)=O.C[C@]1(N4)C3=C(C=CC=C3)C[C@@H]4C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-MK 801 maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.37	10 with gentle warming
	DMSO	33.74	100

Preparing Stock Solutions for (+)-MK 801 maleate

The following data is based on the product molecular weight 337.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.82 mL	29.64 mL
5 mM	0.59 mL	2.96 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for (+)-MK 801 maleate

References are publications that support the biological activity of the product.

Ding Effect of NMDA on proliferation and apoptosis in hippocampal neural stem cells treated with MK-801. Exp.Ther.Med. 2018 PMID: 30116364
Carey Effects of dizocilpine (MK-801) on motor activity and memory. Psychopharmacology 1998 PMID: 9683001
Zajaczkowski Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 1997 PMID: 9257940
Wong The anticonvulsant MK 801 is a potent N-MthD.-aspartate antagonist. Proc.Natl.Acad.Sci.U.S.A. 1986 PMID: 3529096
Hatfield The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model. Eur.J.Pharmacol. 1992 PMID: 1526248
Gill The neuroprotective action of dizocilpine (MK-801) in the rat middle cerebral artery occlusion model of focal ischaemia. Br.J.Pharmacol. 1991 PMID: 1912992