AT 101

Name: AT 101
Brand: Tocris Bioscience
SKU: 3367

Tocris Bioscience, part of Bio-Techne | Catalog # 3367

Citations (10)

COA / SDS

Downregulates Bcl-2 and Mcl-1; pro-apoptotic

Key Product Details

Chemical Name:	(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
Purity:	≥98%
Molecular Weight:	518.56 kDa

View Full Technical Details for AT 101

Technical Data
Citations

Biological Activity for AT 101

AT 101 is a R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo.

Technical Data for AT 101

M. Wt	518.56 kDa
Formula	C₃₀H₃₀O₈
Storage	Store at -20°C
Purity	≥98%
CAS Number	90141-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AT 101

Solubility

Soluble Soluble to 20 mM in DMSO

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References for AT 101

References are publications that support the biological activity of the product.

Balakrishnan et al. AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance. Blood, 2009;113:149 PMID: 18836097
Kline et al. R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells. Exp.Hematol., 2008;36:568 PMID: 18346839
Loberg et al. In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia, 2007;9:1030 PMID: 18084610