AT 7867

Name: AT 7867
Brand: Tocris Bioscience
SKU: 7001

Tocris Bioscience, part of Bio-Techne | Catalog # 7001

Citations (6)

COA / SDS

Potent pan-Akt and PKA inhibitor

Key Product Details

Description:	Potent pan-Akt and PKA inhibitor
Chemical Name:	4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	374.31

View Full Technical Details for AT 7867

Technical Data
Citations

Biological Activity for AT 7867

AT 7867 is a potent pan-Akt (protein kinase B) and protein kinase A (PKA) inhibitor (IC₅₀ values are 32, 17, 47 and 20 nM for Akt1, Akt2, Akt3 and PKA, respectively). Also inhibits p70-S6 kinase (p70S6K, IC₅₀ = 85 nM). Inhibits Akt signaling and proliferation of multiple human cancer cell lines, including breast, prostate and colon. Promotes proliferation of iPSC-derived PDX1⁺ pancreatic progenitor cells (PPCs).

Compound Libraries for AT 7867

AT 7867 is also offered as part of the Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for AT 7867

M. Wt	374.31
Formula	C₂₀H₂₀ClN₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2624336-89-4
InChi Key	YZMRULKVIVBSAA-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C2(C3=CC=C(C4=CNN=C4)C=C3)CCNCC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AT 7867

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.43	100
	ethanol	3.74	10

Preparing Stock Solutions for AT 7867

The following data is based on the product molecular weight 374.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.67 mL	13.36 mL	26.72 mL
5 mM	0.53 mL	2.67 mL	5.34 mL
10 mM	0.27 mL	1.34 mL	2.67 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

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References for AT 7867

References are publications that support the biological activity of the product.

Kimura Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells. Stem Cell Res. 2017 PMID: 28843156
Grimshaw AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. Mol.Cancer Ther. 2010 PMID: 20423992