Atipamezole hydrochloride

Name: Atipamezole hydrochloride
Brand: Tocris Bioscience
SKU: 2937
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2937

(1)

Citations (7)

COA / SDS

Selective α2 antagonist

Key Product Details

Description:	Selective α₂ antagonist
Chemical Name:	5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	248.75

View Full Technical Details for Atipamezole hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Atipamezole hydrochloride

Atipamezole hydrochloride is a selective α₂-adrenergic receptor antagonist (K_i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α_2A, α_2B, α_2C, α_1A and α_1B receptors respectively). Brain penetrant.

Compound Libraries for Atipamezole hydrochloride

Atipamezole hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Atipamezole hydrochloride

M. Wt	248.75
Formula	C₁₄H₁₆N₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	104075-48-1
PubChem ID	13649426
InChi Key	PCCVCJAQMHDWJY-UHFFFAOYSA-N
Smiles	CCC2(C3=CN=CN3)CC1=CC=CC=C1C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Atipamezole hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	24.87	100
	DMSO	24.87	100

Preparing Stock Solutions for Atipamezole hydrochloride

The following data is based on the product molecular weight 248.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.02 mL	20.10 mL	40.20 mL
5 mM	0.80 mL	4.02 mL	8.04 mL
10 mM	0.40 mL	2.01 mL	4.02 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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Reconstitution Calculator

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References for Atipamezole hydrochloride

References are publications that support the biological activity of the product.

Puurunen An α₂-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 2001 PMID: 11249969
Jurgens α_2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 2007 PMID: 17341653
Virtanen Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 1989 PMID: 2567152