ATPA

Name: ATPA
Brand: Tocris Bioscience
SKU: 1107

Tocris Bioscience, part of Bio-Techne | Catalog # 1107

Citations (39)

COA / SDS

Potent and selective GluK1 kainate agonist

Key Product Details

Description:	Potent and selective GluK1 kainate agonist
Chemical Name:	(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	228.25

View Full Technical Details for ATPA

Technical Data
Citations

Biological Activity for ATPA

ATPA is a selective and potent GluK1 (formerly GluR5) kainate receptor agonist (K_i = 4.3 nM), inactive at GluK6 (formerly GluR6) (K_i > 1 mM) and only weakly active at AMPA receptors (GluA1-4) and the kainate receptors GluK5 (formerly KA-2) and GluK3 (formerly GluR7) (K_i values of 6 - 14 μM).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for ATPA

M. Wt	228.25
Formula	C₁₀H₁₆N₂O₄
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	140158-50-5
PubChem ID	2253
InChi Key	PIXJURSCCVBKRF-UHFFFAOYSA-N
Smiles	CC(C)(C)C1=C(CC(N)C(O)=O)C(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ATPA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.28	10 with gentle warming
	1eq. NaOH	4.57	20 with gentle warming

Preparing Stock Solutions for ATPA

The following data is based on the product molecular weight 228.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	21.91 mL	109.53 mL	219.06 mL
1 mM	4.38 mL	21.91 mL	43.81 mL
2 mM	2.19 mL	10.95 mL	21.91 mL
10 mM	0.44 mL	2.19 mL	4.38 mL

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Reconstitution Calculator

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References for ATPA

References are publications that support the biological activity of the product.

Matzen AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazole bioisasteres of glutamic acid. J.Med.Chem. 1997 PMID: 9046343
Moldrich Excitotoxic injury profiles of low-affinity kainate receptor agonists in neuronal cultures. Eur.J.Pharmacol. 1999 PMID: 10478637
Clarke A hippocampal GluR5 kainate receptor regulating inhibitory synaptic transmission. Nature 1997 PMID: 9335499