AZ 20

Name: AZ 20
Brand: Tocris Bioscience
SKU: 5198
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5198

(1)

Citations (30)

COA / SDS

Potent and selective ATR kinase inhibitor; antitumor

Key Product Details

Description:	Potent and selective ATR kinase inhibitor; antitumor
Chemical Name:	4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole
Purity:	≥98% (HPLC)
Molecular Weight:	412.51

View Full Technical Details for AZ 20

Technical Data
Citations / Reviews (1)

Biological Activity for AZ 20

AZ 20 is a potent and selective ATR kinase inhibitor (IC₅₀ = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo.

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries for AZ 20

AZ 20 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 20

M. Wt	412.51
Formula	C₂₁H₂₄N₄O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1233339-22-4
PubChem ID	46244454
InChi Key	SCGCBAAYLFTIJU-CQSZACIVSA-N
Smiles	CS(C4(CC4)C1=CC(N5[C@H](C)COCC5)=NC(C2=CC=CC3=C2C=CN3)=N1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 20

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	20.63	50
	ethanol	4.13	10

Preparing Stock Solutions for AZ 20

The following data is based on the product molecular weight 412.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.85 mL	24.24 mL	48.48 mL
2.5 mM	0.97 mL	4.85 mL	9.70 mL
5 mM	0.48 mL	2.42 mL	4.85 mL
25 mM	0.10 mL	0.48 mL	0.97 mL

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References for AZ 20

References are publications that support the biological activity of the product.

Foote Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J.Med.Chem. 2013 PMID: 23394205