AZ 5704

Name: AZ 5704
Brand: Tocris Bioscience
SKU: 6330

Tocris Bioscience, part of Bio-Techne | Catalog # 6330

COA / SDS

Potent and selective ATM kinase inhibitor; orally bioavailable

Key Product Details

Description:	Potent and selective ATM kinase inhibitor; orally bioavailable
Chemical Name:	7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	434.47

View Full Technical Details for AZ 5704

Technical Data
Citations

Biological Activity for AZ 5704

AZ 5704 is a potent and selective ATM kinase inhibitor (IC₅₀ = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC₅₀ = 0.33 μM). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan (CPT 11, Cat. No. 2688) in tumor bearing, immunocompromised mice. Orally bioavailable.

Compound Libraries for AZ 5704

AZ 5704 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 5704

M. Wt	434.47
Formula	C₂₃H₂₃FN₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1941214-06-7
PubChem ID	130470684
InChi Key	XHNKFGYYGPLYPT-ZDUSSCGKSA-N
Smiles	COCC1=NC=C(C2=CC3=C(N=CC(C(N)=O)=C3N[C@H](C4=NN(C=C4)C)C)C=C2F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 5704

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.45	100

Preparing Stock Solutions for AZ 5704

The following data is based on the product molecular weight 434.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.51 mL	23.02 mL
5 mM	0.46 mL	2.30 mL	4.60 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for AZ 5704

References are publications that support the biological activity of the product.

Degorce Discovery of novel 3-quinoline carboxamides as potent, selective and orally bioavailable inhibitors of ataxia telangiectasia mutated (ATM) kinase. J.Med.Chem. 2016 PMID: 27259031