AZD 6482

Name: AZD 6482
Brand: Tocris Bioscience
SKU: 4839

Tocris Bioscience, part of Bio-Techne | Catalog # 4839

Citations (1)

COA / SDS

Potent and selective PI 3-Kβ inhibitor

Key Product Details

Description:	Potent and selective PI 3-Kβ inhibitor
Chemical Name:	(-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Purity:	≥98%
Molecular Weight:	408.45

View Full Technical Details for AZD 6482

Technical Data
Citations

Biological Activity for AZD 6482

AZD 6482 is a potent and selective inhibitor of PI 3-kinase β (PI 3-Kβ) (IC₅₀ values are 0.69, 13.6, 47.8 and 136 nM for PI 3-Kβ, PI 3-Kδ, PI 3-Kγ and PI 3-Kα, respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZD 6482

AZD 6482 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 6482

M. Wt	408.45
Formula	C₂₂H₂₄N₄O₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	1173900-33-8
PubChem ID	44137675
InChi Key	IRTDIKMSKMREGO-OAHLLOKOSA-N
Smiles	OC(C1=C(N[C@@H](C2=CC(C)=CN3C2=NC(N4CCOCC4)=CC3=O)C)C=CC=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 6482

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.84	100
	1eq. HCl	4.08	10

Preparing Stock Solutions for AZD 6482

The following data is based on the product molecular weight 408.45.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.90 mL
10 mM	0.24 mL	1.22 mL	2.45 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for AZD 6482

References are publications that support the biological activity of the product.

Ni Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 PMID: 22588880
Nylander Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and Ins sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J.Thromb.Haemost. 2012 PMID: 22906130