Azithromycin

Name: Azithromycin
Brand: Tocris Bioscience
SKU: 3771
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3771

(1)

Citations (14)

COA / SDS

Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation

Key Product Details

Description:	Antibiotic; inhibits 50S ribosomal subunit formation and elongation at transpeptidation
Alternative Names:	CP 62993
Chemical Name:	13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one
Purity:	≥99% (HPLC)
Molecular Weight:	748.98

View Full Technical Details for Azithromycin

Technical Data
Citations / Reviews (1)

Biological Activity for Azithromycin

Azithromycin is a macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models. Inhibits autophagy. Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for Azithromycin

Azithromycin is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Azithromycin

M. Wt	748.98
Formula	C₃₈H₇₂N₂O₁₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	83905-01-5
PubChem ID	447043
InChi Key	MQTOSJVFKKJCRP-BICOPXKESA-N
Smiles	[H][C@@]1(O[C@@H]([C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)N2C)=O)O[C@@H](C)[C@H](O)[C@](C)(OC)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Azithromycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	74.9	100
	ethanol	74.9	100

Preparing Stock Solutions for Azithromycin

The following data is based on the product molecular weight 748.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.34 mL	6.68 mL	13.35 mL
5 mM	0.27 mL	1.34 mL	2.67 mL
10 mM	0.13 mL	0.67 mL	1.34 mL
50 mM	0.03 mL	0.13 mL	0.27 mL

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References for Azithromycin

References are publications that support the biological activity of the product.

Sandeep and McGregor Energetics based modeling of hydroxychloroquine and azithromycin binding to the SARS-CoV-2 spike (S) protein - ACE2 complex. ChemRxiv - Paper not yet peer reviewed.
Galluzzi Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 2017 PMID: 28529316
Girard Pharmacokinetic and in vivo studies with azithro. (CP-62,993), a new macrolide with extended half-life and excellent tissue distribution. Antimicrob.Agents Chemother. 1987 PMID: 2830841
Champney and Burdine Macrolide antibiotics inhibit 50S ribosomal subunit assembly in Bacillus subtilis and Staphylococcus aureas. Antimicrob.Agents Chemother. 1995 PMID: 8540733
Retsema Spectrum and mode of action of azithro. (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms. Antimicrob.Agents Chemother. 1987 PMID: 2449865