AZM 475271

Name: AZM 475271
Brand: Tocris Bioscience
SKU: 3963

Tocris Bioscience, part of Bio-Techne | Catalog # 3963

Citations (13)

COA / SDS

Src tyrosine kinase inhibitor

Key Product Details

Description:	Src tyrosine kinase inhibitor
Chemical Name:	N-(2-Chloro-5-methoxyphenyl)-6-methoxy
Purity:	≥99% (HPLC)
Molecular Weight:	442.94

View Full Technical Details for AZM 475271

Technical Data
Citations

Biological Activity for AZM 475271

AZM 475271 is a src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo. Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Compound Libraries for AZM 475271

AZM 475271 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for AZM 475271

M. Wt	442.94
Formula	C₂₃H₂₇ClN₄O₃
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	476159-98-5
PubChem ID	5330175
InChi Key	WPOXAFXHRJYEIC-UHFFFAOYSA-N
Smiles	ClC1=CC=C(OC)C=C1NC3=NC=NC2=CC(OCC4CCN(C)CC4)=C(OC)C=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZM 475271

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.29	100

Preparing Stock Solutions for AZM 475271

The following data is based on the product molecular weight 442.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.29 mL	22.58 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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References for AZM 475271

References are publications that support the biological activity of the product.

Summy AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular endothelial growth factor and interleukin-8 expression in human solid tumor cell lines and abrogates downstream angiogenic processes. Mol.Cancer Ther. 2005 PMID: 16373705
Yezhelyev Inhibition of Src tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin.Cancer Res. 2004 PMID: 15585638