B I09

Name: B I09
Brand: Tocris Bioscience
SKU: 6009

Tocris Bioscience, part of Bio-Techne | Catalog # 6009

Citations (2)

COA / SDS

IRE1 endonuclease inhibitor; cell permeable

Key Product Details

Chemical Name:	7-(1,3-Dioxan-2-yl)-1,2,3,4-tetrahydro-8-hydroxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one
Purity:	≥98%

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Technical Data
Citations

Biological Activity for B I09

B I09 is an IRE-1 RNase inhibitor (IC₅₀ = 1.23 μM). Inhibits IRE-1/XBP1 pathway. Cell permeable. Inhibits growth of human chronic lymphocytic leukemia (CLL) cells in vitro and promotes CLL regression in a mouse model.

Technical Data for B I09

Formula	C₁₆H₁₇NO₅
Storage	Store at -20°C
Purity	≥98%
CAS Number	1607803-67-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for B I09

Solubility

Soluble Soluble to 50 mM in DMSO

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References for B I09

References are publications that support the biological activity of the product.

Tang et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J.Clin.Invest., 2014;124:2585 PMID: 24812669

B I09

Tocris Bioscience, part of Bio-Techne | Catalog # 6009

Key Product Details

Biological Activity for B I09

Technical Data for B I09

Solubility for B I09

Dilution Calculator

Reconstitution Calculator

References for B I09

Product Documents for B I09

COA

Certificate of Analysis

SDS

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