Bafilomycin A1

Biological Activity for Bafilomycin A1

Technical Data for Bafilomycin A1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bafilomycin A1

References for Bafilomycin A1

References are publications that support the biological activity of the product.

• ND Okerlund, K Schneider, S Leal-Ortiz, C Montenegro, SA Kim, LC Garner, ED Gundelfing, RJ Reimer, CC Garner Bassoon Controls Presynaptic Autophagy through Atg5 Neuron, 2017;93(4):897-913.e7. 2017 PMID: 28231469
• S Lee, JY Lee, EW Lee, S Park, DH Kang, C Min, DJ Lee, D Kang, J Song, J Kwon, SW Kang Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-?-Induced Apoptosis via Different Routes Cell Rep, 2019;26(8):2194-2211.e6. 2019 PMID: 30784599
• Kurokawa S, Hill K, McDonald W, Burk R Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2). J Biol Chem, 2012;287(34):28717-26. 2012 PMID: 22761431
• Kirsten Lauber Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance Cancer Lett., 2016;386(0):87-99. 2016 PMID: 27867017
• Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura S, Nakayama K, Kuwano K Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 2014;192(3):958-68. 2014 PMID: 24367027
• Steinberg F, Heesom KJ, Bass MD, Cullen PJ SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. J. Cell Biol., 2012;197(2):219-30. 2012 PMID: 22492727
• Zhu X, Messer J, Wang Y, Lin F, Cham C, Chang J, Billiar T, Lotze M, Boone D, Chang E Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest, 2015;125(3):1098-110. 2015 PMID: 25642769
• L Kinzel, A Ernst, M Orth, V Albrecht, R Hennel, N Brix, B Frey, US Gaipl, G Zuchtriege, CA Reichel, A Blutke, D Schilling, G Multhoff, M Li, M Niyazi, AA Friedl, N Winssinger, C Belka, K Lauber A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer Oncotarget, 2016;7(28):43199-43219. 2016 PMID: 27259245
• Williamson R, Cowell C, Reville T, Roper J, Rendall T, Bass M Coronin-1C Protein and Caveolin Protein Provide Constitutive and Inducible Mechanisms of Rac1 Protein Trafficking. J Biol Chem, 2015;290(25):15437-49. 2015 PMID: 25925950
• N Nishijima, T Hirai, K Misato, M Aoyama, E Kuroda, KJ Ishii, K Higashisak, Y Yoshioka, Y Tsutsumi Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific Front Immunol, 2017;8(0):379. 2017 PMID: 28421077
• E Jacquin, S Leclerc-Me, C Judon, E Blanchard, S Fraitag, O Florey Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation Autophagy, 2017;0(0):1-14. 2017 PMID: 28296541
• Mauthe M, Orhon I, Rocchi C et al. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018-07-20 PMID: 29940786
• Yamamoto et al. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct.Funct., 1998;23:33 PMID: 9639028
• Fass et al. Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes. J.Biol.Chem., 2006;281:36303 PMID: 16963441
• Gagliardi et al. Chemistry and stucture activity relationships of bafilomycin A₁, a potent and selective inhibitor of the vacuolar H⁺-ATPase. Curr.Med.Chem., 1999;6:1197 PMID: 10519916