BAM 22P

Name: BAM 22P
Brand: Tocris Bioscience
SKU: 1650

Tocris Bioscience, part of Bio-Techne | Catalog # 1650

Citations (1)

COA / SDS

MRGPRX1 agonist; also opioid receptor agonist

Discontinued Product

1650 has been discontinued. View all Miscellaneous/Non-selective Opioid Agonists products.

Key Product Details

Description:	MRGPRX1 agonist; also opioid receptor agonist
Alternative Names:	Bovine adrenal medullary peptide-22P,BAM 22 (1-22)
Molecular Weight:	2839.24

View Full Technical Details for BAM 22P

Technical Data
Citations

Biological Activity for BAM 22P

Potent endogenous agonist peptide for Mas-related G proteins-coupled receptor X1 (MRGPRX1); isolated from bovine adrenal medulla (EC₅₀ values are 16 - 800 nM) Also potent opioid agonist (IC₅₀ = 1.3 nM in guinea pig ileum preparation). Produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.

Technical Data for BAM 22P

M. Wt	2839.24
Formula	C₁₃₀H₁₈₄N₃₈O₃₁S₂
Single Letter Sequence	YGGFMRRVGRPEWWMDYQKRYG
Storage	Desiccate at -20°C
CAS Number	76622-26-9
PubChem ID	16132339
InChi Key	QYDAFJUKVGVEKO-PKOVDKIBSA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BAM 22P

References are publications that support the biological activity of the product.

Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Simonin and Kieffer Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 2002 PMID: 11865303
Lembo Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 2002 PMID: 11850634
Mizuno A new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem.Biophys.Res.Commun. 1980 PMID: 7213356
Hong Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 2004 PMID: 14718254

BAM 22P

Tocris Bioscience, part of Bio-Techne | Catalog # 1650

Key Product Details

Biological Activity for BAM 22P

Technical Data for BAM 22P

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BAM 22P

Product Documents for BAM 22P

COA

Certificate of Analysis

SDS

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