BAPTA AM

Name: BAPTA AM
Brand: Tocris Bioscience
SKU: 2787

Tocris Bioscience, part of Bio-Techne | Catalog # 2787

(1)

Citations (178)

COA / SDS

Cell-permeable Ca2+ chelator

Key Product Details

Chemical Name:	1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
Purity:	≥95%
Molecular Weight:	764.68 kDa

View Full Technical Details for BAPTA AM

Technical Data
Citations / Reviews (1)

Biological Activity for BAPTA AM

BAPTA AM is a selective calcium chelator that is the cell-permeable analog of BAPTA (Cat. No. 2786). Blocks hK_v1.5, hK_V11.1 (hERG) and hK_v1.3 channels (K_i values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

F 127 (Cat. No. 6253) for the solubilization of BAPTA AM is also available.

Technical Data for BAPTA AM

M. Wt	764.68 kDa
Formula	C₃₄H₄₀N₂O₁₈
Storage	Store at -20°C
Purity	≥95%
CAS Number	126150-97-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAPTA AM

Solubility

Soluble Soluble to 30 mM in DMSO

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References for BAPTA AM

References are publications that support the biological activity of the product.

SG Cho APC downregulated 1 inhibits breast cancer cell invasion by inhibiting the canonical WNT signaling pathway Oncol Lett, 2017;14(4):4845-4852. 2017 PMID: 29085490
Z Shen, Y Chen, L Hong, Z Cui, H Yang, X He, Y Shi, L Shi, F Han, N Zhou BNGR-A25L and -A27 are two functional G protein-coupled receptors for CAPA periviscerokinin neuropeptides in the silkworm, Bombyx mori J. Biol. Chem., 2017;0(0):. 2017 PMID: 28842502
Goggs R, Harper M, Pope R, Savage J, Williams C, Mundell S, Heesom K, Bass M, Mellor H, Poole A RhoG protein regulates platelet granule secretion and thrombus formation in mice. J Biol Chem, 2013;288(47):34217-29. 2013 PMID: 24106270
HJ Lee, MF Diaz, A Ewere, SD Olson, CS Cox, PL Wenzel Focal adhesion kinase signaling regulates anti-inflammatory function of bone marrow mesenchymal stromal cells induced by biomechanical force Cell. Signal., 2017;38(0):9-Jan. 2017 PMID: 28647573
Ghislat G, Patron M, Rizzuto R, Knecht E Withdrawal of essential amino acids increases autophagy by a pathway involving Ca2+/calmodulin-dependent kinase kinase-beta (CaMKK-beta). J Biol Chem, 2012;287(46):38625-36. 2012 PMID: 23027865
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012;492(7427):123-7. 2012 PMID: 23143333
Raspe et al. Enhanced release of prostacyclin from quin 2-loaded endothelial cells. Eur.J.Pharmacol., 1989;163:345 PMID: 2498111
Tang et al. The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem.Pharmacol., 2007;74:1596 PMID: 17826747
Heilporn et al. Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin. Bull.Soc.Chim.Belg., 1994;103:309