Batimastat

Name: Batimastat
Brand: Tocris Bioscience
SKU: 2961
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2961

(1)

Citations (82)

COA / SDS

Potent, broad spectrum MMP inhibitor

Key Product Details

Description:	Potent, broad spectrum MMP inhibitor
Alternative Names:	BB-94
Chemical Name:	(2R,3S)-N⁴-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
Purity:	≥99% (HPLC)
Molecular Weight:	477.64

View Full Technical Details for Batimastat

Technical Data
Citations / Reviews (1)

Biological Activity for Batimastat

Batimastat is a potent, broad spectrum MMP inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.

Technical Data for Batimastat

M. Wt	477.64
Formula	C₂₃H₃₁N₃O₄S₂
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	130370-60-4
PubChem ID	5362422
InChi Key	XFILPEOLDIKJHX-QYZOEREBSA-N
Smiles	O=[C@]([C@H](CC(C)C)[C@@H]([C@](NO)=O)CSC2=CC=CS2)N[C@H](C(NC)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Batimastat

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.76	100

Preparing Stock Solutions for Batimastat

The following data is based on the product molecular weight 477.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.09 mL	10.47 mL	20.94 mL
5 mM	0.42 mL	2.09 mL	4.19 mL
10 mM	0.21 mL	1.05 mL	2.09 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for Batimastat

References are publications that support the biological activity of the product.

Wang Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 1994 PMID: 8062271
Kohn and Liotta Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 1995 PMID: 7728753
Davies A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 1993 PMID: 8347186