Bax channel blocker

Name: Bax channel blocker
Brand: Tocris Bioscience
SKU: 2160

Tocris Bioscience, part of Bio-Techne | Catalog # 2160

Citations (9)

COA / SDS

Allosteric inhibitor of Bax channel activation

Key Product Details

Description:	Allosteric inhibitor of Bax channel activation
Alternative Names:	BAI1
Chemical Name:	3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	540.12

View Full Technical Details for Bax channel blocker

Technical Data
Citations

Biological Activity for Bax channel blocker

Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC₅₀ = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC₅₀ = 0.52 μM).

Compound Libraries for Bax channel blocker

Bax channel blocker is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Bax channel blocker

M. Wt	540.12
Formula	C₁₉H₂₁Br₂N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	329349-20-4
PubChem ID	2729026
InChi Key	HWFKCAFKXZFOQT-UHFFFAOYSA-N
Smiles	Cl.Cl.OC(CN1C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2)CN1CCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bax channel blocker

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	2.34	5
	DMSO	46.72	100

Preparing Stock Solutions for Bax channel blocker

The following data is based on the product molecular weight 540.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.26 mL	18.51 mL
5 mM	0.37 mL	1.85 mL	3.70 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for Bax channel blocker

References are publications that support the biological activity of the product.

Garner Small-molecule allosteric inhibitors of BAX. Nat.Chem.Biol. 2019 PMID: 30718816
Bombrun 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem.