Bax channel blocker

Name: Bax channel blocker
Brand: Tocris Bioscience
SKU: 2160

Tocris Bioscience, part of Bio-Techne | Catalog # 2160

Citations (9)

COA / SDS

Allosteric inhibitor of Bax channel activation

Key Product Details

Chemical Name:	3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride
Purity:	≥98%
Molecular Weight:	540.12 kDa

View Full Technical Details for Bax channel blocker

Technical Data
Citations

Biological Activity for Bax channel blocker

Bax channel blocker is a allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC₅₀ = 3.3 μM). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC₅₀ = 0.52 μM).

Technical Data for Bax channel blocker

M. Wt	540.12 kDa
Formula	C₁₉H₂₁Br₂N₃O.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	329349-20-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bax channel blocker

Solubility

Soluble Soluble to 5 mM in water and to 100 mM in DMSO

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References for Bax channel blocker

References are publications that support the biological activity of the product.

Bombrun et al. 3,6-Dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J.Med.Chem., 2003;46:21
Garner et al. Small-molecule allosteric inhibitors of BAX. Nat.Chem.Biol., 2019;15:322 PMID: 30718816