Bay 11-7085

Name: Bay 11-7085
Brand: Tocris Bioscience
SKU: 1743

Tocris Bioscience, part of Bio-Techne | Catalog # 1743

Citations (27)

COA / SDS

Irreversible inhibitor of TNF-α-induced IκBα phosphorylation

Key Product Details

Description:	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
Alternative Names:	Bay 11-7083
Chemical Name:	(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
Purity:	≥98% (HPLC)
Molecular Weight:	249.33

View Full Technical Details for Bay 11-7085

Technical Data
Citations

Biological Activity for Bay 11-7085

Bay 11-7085 is an irreversible inhibitor of TNF-α-stimulated IκBα phosphorylation (IC₅₀ ~ 10 μM); leads to decreased NF-κB and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo.

Compound Libraries for Bay 11-7085

Bay 11-7085 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Bay 11-7085

M. Wt	249.33
Formula	C₁₃H₁₅NO₂S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	196309-76-9
PubChem ID	5353432
InChi Key	VHKZGNPOHPFPER-ONNFQVAWSA-N
Smiles	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bay 11-7085

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	24.93	100
	DMSO	24.93	100

Preparing Stock Solutions for Bay 11-7085

The following data is based on the product molecular weight 249.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.01 mL	20.05 mL	40.11 mL
5 mM	0.80 mL	4.01 mL	8.02 mL
10 mM	0.40 mL	2.01 mL	4.01 mL
50 mM	0.08 mL	0.40 mL	0.80 mL

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References for Bay 11-7085

References are publications that support the biological activity of the product.

Pierce Novel inhibitors of cytokine-induced IkBa phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 1997 PMID: 9261113
Scaife Nuclear factor κB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 2002 PMID: 12460901
Hu An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism. Cancer Res. 2001 PMID: 11507084