Bay 11-7821

Name: Bay 11-7821
Brand: Tocris Bioscience
SKU: 1744

Tocris Bioscience, part of Bio-Techne | Catalog # 1744

Citations (13)

COA / SDS

E2 ubiquitin (Ub) conjugating enzymes inhibitor

Key Product Details

Description:	E2 ubiquitin (Ub) conjugating enzymes inhibitor
Alternative Names:	Bay 11-7082
Chemical Name:	(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Purity:	≥99% (HPLC)
Molecular Weight:	207.25

View Full Technical Details for Bay 11-7821

Technical Data
Citations

Biological Activity for Bay 11-7821

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

Technical Data for Bay 11-7821

M. Wt	207.25
Formula	C₁₀H₉NO₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	19542-67-7
PubChem ID	5353431
InChi Key	DOEWDSDBFRHVAP-KRXBUXKQSA-N
Smiles	CC1=CC=C(C=C1)S(=O)(=O)\C=C\C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bay 11-7821

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	5.18	25
	DMSO	20.73	100

Preparing Stock Solutions for Bay 11-7821

The following data is based on the product molecular weight 207.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.83 mL	24.13 mL	48.25 mL
5 mM	0.97 mL	4.83 mL	9.65 mL
10 mM	0.48 mL	2.41 mL	4.83 mL
50 mM	0.10 mL	0.48 mL	0.97 mL

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References for Bay 11-7821

References are publications that support the biological activity of the product.

Pandeya Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm 2019 PMID: 31191857
Juliana Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J.Biol.Chem. 2010 PMID: 20093358
Pierce Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem. 1997 PMID: 9261113
Strickson The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J. 2013 PMID: 23441730
Mori Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 2002 PMID: 12176906