BAY 1797

Name: BAY 1797
Brand: Tocris Bioscience
SKU: 7573

Tocris Bioscience, part of Bio-Techne | Catalog # 7573

COA / SDS

Selective P2X4 antagonist

Key Product Details

Description:	Selective P2X₄ antagonist
Chemical Name:	N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	416.88

View Full Technical Details for BAY 1797

Technical Data
Citations

Biological Activity for BAY 1797

BAY 1797 is a selective purinergic P2X₄ receptor antagonist (IC₅₀ values are 108, 112 and 233 nM for the human, mouse and rat P2X₄, respectively). It is selective for P2X₄ over P2X₃, P2X₇, and P2X₁ receptors (IC₅₀ values are 8.3, 10.6 and >50 μM, respectively, for the human receptors). BAY 1797 dose-dependently reduces prostaglandin E₂ levels and exhibits anti-inflammatory and analgesic effects in an in vivo model of inflammatory pain. Orally active.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY 1797 probe summary on the SGC website.

Technical Data for BAY 1797

M. Wt	416.88
Formula	C₂₀H₁₇ClN₂O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2055602-83-8
PubChem ID	124125214
InChi Key	CSJYMAFXYMYNCK-UHFFFAOYSA-N
Smiles	NS(=O)(C1=C(C=CC(NC(CC2=CC=CC=C2)=O)=C1)OC3=CC(Cl)=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 1797

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.69	100
	ethanol	41.69	100

Preparing Stock Solutions for BAY 1797

The following data is based on the product molecular weight 416.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.40 mL	11.99 mL	23.99 mL
5 mM	0.48 mL	2.40 mL	4.80 mL
10 mM	0.24 mL	1.20 mL	2.40 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for BAY 1797

References are publications that support the biological activity of the product.

Werner Discovery and characterization of the potent and selective P2X₄ inhibitor N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of its CYP3A4 induction profile. J.Med.Chem. 2019 PMID: 31746599