BAY 41-8543

Name: BAY 41-8543
Brand: Tocris Bioscience
SKU: 5708

Tocris Bioscience, part of Bio-Techne | Catalog # 5708

Citations (1)

COA / SDS

Guanylyl cyclase (sGC) stimulator

Key Product Details

Description:	Guanylyl cyclase (sGC) stimulator
Chemical Name:	2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
Purity:	≥98% (HPLC)
Molecular Weight:	420.44

View Full Technical Details for BAY 41-8543

Technical Data
Citations

Biological Activity for BAY 41-8543

BAY 41-8543 is a guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Technical Data for BAY 41-8543

M. Wt	420.44
Formula	C₂₁H₂₁FN₈O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	256498-66-5
PubChem ID	9953906
InChi Key	AQYFUZRYBJBAGZ-UHFFFAOYSA-N
Smiles	FC1=CC=CC=C1CN2N=C(C3=NC(N)=C(N4CCOCC4)C(N)=N3)C5=CC=CN=C52

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 41-8543

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.2	10 with gentle warming

Preparing Stock Solutions for BAY 41-8543

The following data is based on the product molecular weight 420.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.78 mL	118.92 mL	237.85 mL
0.5 mM	4.76 mL	23.78 mL	47.57 mL
1 mM	2.38 mL	11.89 mL	23.78 mL
5 mM	0.48 mL	2.38 mL	4.76 mL

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References for BAY 41-8543

References are publications that support the biological activity of the product.

Hoffmann Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat.Commun. 2015 PMID: 26011238
Stasch Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br.J.Pharmacol. 2002 PMID: 11815368