BAY 593

Name: BAY 593
Brand: Tocris Bioscience
SKU: 8113

Tocris Bioscience, part of Bio-Techne | Catalog # 8113

COA / SDS

Geranylgeranyltransferase-I (GGTase-1) inhibitor

Key Product Details

Description:	Geranylgeranyltransferase-I (GGTase-1) inhibitor
Chemical Name:	(2R)-3,3,3-Trifluoro-2-methoxy-1-[(7R)-7-(2-methoxyphenyl)-3,9-diazaspiro[5.5]undec-3-yl]-2-phenyl-1-propanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	513

View Full Technical Details for BAY 593

Technical Data
Citations

Biological Activity for BAY 593

BAY 593 is a geranylgeranyltransferase-I (GGTase-1) inhibitor. Blocks activation of Rho-GTPases to inactivate YAP1/TAZ signaling. Dose-dependently inhibits growth of tumors in xenograft mouse models (IC₅₀ values are 38.4 nM and 564 nM in MT-1080 and MDA-MB-231 cells respectively) and PXF 541 xenografts. Orally bioavailable and suitable for use in vivo.

Technical Data for BAY 593

M. Wt	513
Formula	C₂₆H₃₁F₃N₂O₃.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2413020-57-0
InChi Key	OCVVGTVEVMMMCR-XSHMPXIGSA-N
Smiles	COC1=C(C=CC=C1)[C@H]2C3(CCNC2)CCN(CC3)C([C@](OC)(C4=CC=CC=C4)C(F)(F)F)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 593

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	51.3	100

Preparing Stock Solutions for BAY 593

The following data is based on the product molecular weight 513.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.75 mL	19.49 mL
5 mM	0.39 mL	1.95 mL	3.90 mL
10 mM	0.19 mL	0.97 mL	1.95 mL
50 mM	0.04 mL	0.19 mL	0.39 mL

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References for BAY 593

References are publications that support the biological activity of the product.

Graham Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell.Chem.Biol. 2024 PMID: 38537632