BAY 805

Name: BAY 805
Brand: Tocris Bioscience
SKU: 7984

Tocris Bioscience, part of Bio-Techne | Catalog # 7984

COA / SDS

Potent and selective inhibitor of USP21; also NF-κB activator

Key Product Details

Description:	Potent and selective inhibitor of USP21; also NF-κB activator
Chemical Name:	N-[(1R)-1-[[[5-[(4-Cyanophenyl)methyl]-1,3,4-thiadiazol-2-yl]amino]carbonyl]-3-methylbutyl]-1-(trifluoromethyl)cyclohexanecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	507.58

View Full Technical Details for BAY 805

Technical Data
Citations

Biological Activity for BAY 805

BAY 805 is a potent and selective inhibitor of USP21 (IC₅₀ = 6 nM, K_d = 2.2 nM). BAY 805 induces NF-κB activation (EC₅₀= 17 nM in a cell-based reporter assay).

Technical Data for BAY 805

M. Wt	507.58
Formula	C₂₄H₂₈F₃N₅O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2925481-88-3
PubChem ID	167312463
InChi Key	LXRBPWHQMGKMRT-GOSISDBHSA-N
Smiles	N#CC(C=C1)=CC=C1CC2=NN=C(S2)NC([C@@H](CC(C)C)NC(C3(CCCCC3)C(F)(F)F)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 805

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	50.76	100
	ethanol	50.76	100

Preparing Stock Solutions for BAY 805

The following data is based on the product molecular weight 507.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.97 mL	9.85 mL	19.70 mL
5 mM	0.39 mL	1.97 mL	3.94 mL
10 mM	0.20 mL	0.99 mL	1.97 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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References for BAY 805

References are publications that support the biological activity of the product.

Göricke Discovery and characterization of BAY-805, a potent and selective inhibitor of ubiquitin-specific protease USP21. J.Med.Chem 2023 PMID: 36802665