Bexarotene

Name: Bexarotene
Brand: Tocris Bioscience
SKU: 5819
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5819

(1)

Citations (11)

COA / SDS

Potent and selective RXR agonist

Key Product Details

Description:	Potent and selective RXR agonist
Alternative Names:	LGD 1069
Chemical Name:	4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
Purity:	≥99% (HPLC)
Molecular Weight:	348.48

View Full Technical Details for Bexarotene

Technical Data
Citations / Reviews (1)

Biological Activity for Bexarotene

Bexarotene is a potent and selective RXR agonist (EC₅₀ values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts.

Technical Data for Bexarotene

M. Wt	348.48
Formula	C₂₄H₂₈O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	153559-49-0
PubChem ID	82146
InChi Key	NAVMQTYZDKMPEU-UHFFFAOYSA-N
Smiles	CC(CCC(C)2C)(C)C1=C2C=C(C)C(C(C3=CC=C(C(O)=O)C=C3)=C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bexarotene

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	34.85	100
	ethanol	6.97	20 with gentle warming

Preparing Stock Solutions for Bexarotene

The following data is based on the product molecular weight 348.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.87 mL	14.35 mL	28.70 mL
5 mM	0.57 mL	2.87 mL	5.74 mL
10 mM	0.29 mL	1.43 mL	2.87 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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Reconstitution Calculator

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References for Bexarotene

References are publications that support the biological activity of the product.

Yen A selective retinoid X receptor agonist bexar. (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 2006 PMID: 16495926
Nie Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 2017 PMID: 28099842
Boehm Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 1994 PMID: 8071941