BI 6015

Name: BI 6015
Brand: Tocris Bioscience
SKU: 4641

Tocris Bioscience, part of Bio-Techne | Catalog # 4641

Citations (4)

COA / SDS

Hepatocyte nuclear factor 4α (HNF4α) antagonist

Key Product Details

Description:	Hepatocyte nuclear factor 4α (HNF4α) antagonist
Chemical Name:	2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole
Purity:	≥98% (HPLC)
Molecular Weight:	331.35

View Full Technical Details for BI 6015

Technical Data
Citations

Biological Activity for BI 6015

BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist. Represses expression of known HNF4α target genes. Decreases HNF4α DNA binding. Exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma.

Compound Libraries for BI 6015

BI 6015 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BI 6015

M. Wt	331.35
Formula	C₁₅H₁₃N₃O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	93987-29-2
PubChem ID	3269393
InChi Key	ILVCPQPMRPHZSG-UHFFFAOYSA-N
Smiles	CC2=NC1=CC=CC=C1N2S(C3=C(C)C=CC([N+]([O-])=O)=C3)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BI 6015

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.63	20

Preparing Stock Solutions for BI 6015

The following data is based on the product molecular weight 331.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.09 mL	75.45 mL	150.90 mL
1 mM	3.02 mL	15.09 mL	30.18 mL
2 mM	1.51 mL	7.54 mL	15.09 mL
10 mM	0.30 mL	1.51 mL	3.02 mL

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Reconstitution Calculator

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References for BI 6015

References are publications that support the biological activity of the product.

Kiselyuk HNF4α antagonists discovered by a high-throughput screen for modulators of the human Ins promoter. Chem.Biol. 2012 PMID: 22840769