BI 78D3

Name: BI 78D3
Brand: Tocris Bioscience
SKU: 3314

Tocris Bioscience, part of Bio-Techne | Catalog # 3314

Citations (11)

COA / SDS

Selective, competitive JNK inhibitor

Key Product Details

Description:	Selective, competitive JNK inhibitor
Chemical Name:	4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
Purity:	≥99% (HPLC)
Molecular Weight:	379.37

View Full Technical Details for BI 78D3

Technical Data
Citations

Biological Activity for BI 78D3

BI 78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC₅₀ = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC₅₀ = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.

Compound Libraries for BI 78D3

BI 78D3 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BI 78D3

M. Wt	379.37
Formula	C₁₃H₉N₅O₅S₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	883065-90-5
PubChem ID	2747117
InChi Key	QFRLDZGQEZCCJZ-UHFFFAOYSA-N
Smiles	O=C1NN=C(SC3=NC=C([N+]([O-])=O)S3)N1C2=CC=C4C(OCCO4)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BI 78D3

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.94	100
	ethanol	1.9	5

Preparing Stock Solutions for BI 78D3

The following data is based on the product molecular weight 379.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.18 mL	26.36 mL
5 mM	0.53 mL	2.64 mL	5.27 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for BI 78D3

References are publications that support the biological activity of the product.

Flight Getting rid of JNK. Nat.Rev.Drug Disc.
Haas and Writer Block JNK at the dock. SCiBX
Stebbins Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc.Natl.Acad.Sci.USA 2008 PMID: 1892277