BIBR 1532

Name: BIBR 1532
Brand: Tocris Bioscience
SKU: 2981

Tocris Bioscience, part of Bio-Techne | Catalog # 2981

(1)

Citations (15)

COA / SDS

Selective telomerase inhibitor

Key Product Details

Chemical Name:	2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Purity:	≥98%
Molecular Weight:	331.36 kDa

View Full Technical Details for BIBR 1532

Technical Data
Citations / Reviews (1)

Biological Activity for BIBR 1532

BIBR 1532 is a selective telomerase inhibitor (IC₅₀ values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Technical Data for BIBR 1532

M. Wt	331.36 kDa
Formula	C₂₁H₁₇NO₃
Storage	Store at RT
Purity	≥98%
CAS Number	321674-73-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIBR 1532

Solubility

Soluble Soluble to 100 mM in DMSO and to 25 mM in ethanol

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References for BIBR 1532

References are publications that support the biological activity of the product.

N Mahfouz, R Tahtouh, N Alaaeddine, J El Hajj, R Sarkis, R Hachem, I Raad, G Hilal Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors PLoS ONE, 2017;12(6):e0179202. 2017 PMID: 28594907
Damm et al. A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J., 2001;20:6958 PMID: 11742973
Phatak and Burger Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol., 2007;152:1003 PMID: 17603541
Rankin et al. Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs, 2008;19:329 PMID: 18454043