BIIB 021

Name: BIIB 021
Brand: Tocris Bioscience
SKU: 4608
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4608

(1)

Citations (1)

COA / SDS

Selective Hsp90 inhibitor

Discontinued Product

4608 has been discontinued. View all HSP90 Inhibitors products.

Key Product Details

Description:	Selective Hsp90 inhibitor
Alternative Names:	CNF 2024
Chemical Name:	6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	318.76

View Full Technical Details for BIIB 021

Technical Data
Citations / Reviews (1)

Biological Activity for BIIB 021

BIIB 021 is a selective, Hsp90 competitive inhibitor (K_i = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na⁺K⁺ ATPase. Induces degradation of HER-2 in vitro (EC₅₀ = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.

Technical Data for BIIB 021

M. Wt	318.76
Formula	C₁₄H₁₅ClN₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	848695-25-0
PubChem ID	16736529
InChi Key	QULDDKSCVCJTPV-UHFFFAOYSA-N
Smiles	ClC1=C2C(N(CC3=NC=C(C)C(OC)=C3C)C=N2)=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for BIIB 021

References are publications that support the biological activity of the product.

Yin BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int.J.Cancer 2010 PMID: 19662650
Lundgren BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol.Cancer Ther. 2009 PMID: 19372565

BIIB 021

Tocris Bioscience, part of Bio-Techne | Catalog # 4608

Key Product Details

Biological Activity for BIIB 021

Technical Data for BIIB 021

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for BIIB 021

Product Documents for BIIB 021

COA

Certificate of Analysis

SDS

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