BIIE 0246 hydrochloride

Name: BIIE 0246 hydrochloride
Brand: Tocris Bioscience
SKU: 7377

Tocris Bioscience, part of Bio-Techne | Catalog # 7377

Citations (4)

COA / SDS

Potent, selective and competitive non-peptide NPY Y2 receptor antagonist; active in vivo

Key Product Details

Description:	Potent, selective and competitive non-peptide NPY Y₂ receptor antagonist; active in vivo
Alternative Names:	BIIE 0246 2HCl,BIIE0246 2HCl
Chemical Name:	N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	968.98

View Full Technical Details for BIIE 0246 hydrochloride

Technical Data
Citations

Biological Activity for BIIE 0246 hydrochloride

BIIE 0246 hydrochloride is a potent, selective and competitive nonpeptide antagonist for the neuropeptide Y Y₂ receptor (IC₅₀ = 15 nM). Displays > 650-fold selectivity for NPY Y₂ over Y₁, Y₄ and Y₅ receptors. Active in vivo.

Technical Data for BIIE 0246 hydrochloride

M. Wt	968.98
Formula	C₄₉H₅₇N₁₁O₆.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	246146-31-6
InChi Key	UESZCTPNTRZXHQ-SICTUBFJSA-N
Smiles	O=C(C1=C2C=CC=C1)NC3=CC=CC=C3C2N(CC4)CCN4C(CC5(CCCC5)CC(N[C@@H](CCCNC(N)=N)C(NCCN6C(N(C7=CC=CC=C7)N(C8=CC=CC=C8)C6=O)=O)=O)=O)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIIE 0246 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	96.9	100

Preparing Stock Solutions for BIIE 0246 hydrochloride

The following data is based on the product molecular weight 968.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.03 mL	5.16 mL	10.32 mL
5 mM	0.21 mL	1.03 mL	2.06 mL
10 mM	0.10 mL	0.52 mL	1.03 mL
50 mM	0.02 mL	0.10 mL	0.21 mL

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References for BIIE 0246 hydrochloride

References are publications that support the biological activity of the product.

Dumont BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y₂ receptor antagonist. Br.J.Pharmacol. 2000 PMID: 10725255
Malmstrom Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y₂ receptor antagonist, in vivo. Br.J.Pharmacol. 2001 PMID: 11487518
Doods BIIE0246: a selective and high affinity neuropeptide Y Y₂ receptor antagonist. Eur.J.Pharmacol. 1999 PMID: 10611450