BIO 1211

Name: BIO 1211
Brand: Tocris Bioscience
SKU: 3910

Tocris Bioscience, part of Bio-Techne | Catalog # 3910

Citations (9)

COA / SDS

Selective α4β1 (VLA-4) inhibitor

Key Product Details

Purity:	≥95%
Molecular Weight:	708.8 kDa

View Full Technical Details for BIO 1211

Technical Data
Citations

Biological Activity for BIO 1211

BIO 1211 is a selective, high affinity α₄β₁ (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α₄β₁ (K_D = 70 pM; IC₅₀ = 0.004 μM). Selective for α₄β₁ over a range of other integrins (IC₅₀ >100 μM for α₁β₁, α₅β₁ and α₆β₁).

Technical Data for BIO 1211

M. Wt	708.8 kDa
Formula	C₃₆H₄₈N₆O₉
Storage	Store at -20°C
Purity	≥95%
CAS Number	187735-94-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIO 1211

Solubility

Soluble Soluble to 2 mg/ml in water

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for BIO 1211

References are publications that support the biological activity of the product.

Kota, Daniel J, DiCarlo, Bryan, Hetz, Robert A, Smith, Philippa, Cox, Charles, Olson, Scott D Differential MSC activation leads to distinct mononuclear leukocyte binding mechanisms. Sci Rep, 2014;4(0):4565. 2014 PMID: 24691433
WS Chen, Z Cao, S Sugaya, MJ Lopez, VG Sendra, N Laver, H Leffler, UJ Nilsson, J Fu, J Song, L Xia, P Hamrah, N Panjwani Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3 Nat Commun, 2016;7(0):11302. 2016 PMID: 27066737
Chen et al. Multiple activation sites of integrin α₄β₁ detected through their different affinities for a small molecule ligand. J.Biol.Chem., 1999;274:13167 PMID: 10224072
Lin et al. Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem., 1999;42:920 PMID: 10072689
Muro et al. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem., 2009;52:7974 PMID: 19891440