BIX 02189

Name: BIX 02189
Brand: Tocris Bioscience
SKU: 4842

Tocris Bioscience, part of Bio-Techne | Catalog # 4842

Citations (12)

COA / SDS

Selective MEK5 and ERK5 inhibitor

Key Product Details

Chemical Name:	(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for BIX 02189

BIX 02189 is a selective MEK5 and ERK5 inhibitor (IC₅₀ values are 1.5 and 59 nM respectively). Inhibits sorbitol-induced ERK5 phosphorylation in HeLa cells. Selective for MEK5 and ERK5 over MEK1/2, ERK1/2 and a panel of 87 kinases. Induces apoptosis in acute myeloid leukemia tumor cells.

Technical Data for BIX 02189

Formula	C₂₇H₂₈N₄O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	1265916-41-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIX 02189

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl

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References for BIX 02189

References are publications that support the biological activity of the product.

Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem.Biophys.Res.Comm., 2008;377:120 PMID: 18834865
Lopez-Royuela et al. Extracellular-signal-regulated kinase 5 modulates the antioxidant response by transcriptionally controlling Sirtuin 1 expression in leukemic cells. Int.J.Biochem.Cell Biol., 2014;53:253 PMID: 24880091
Kimura et al. Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart. Circ.Res., 2010;106:961 PMID: 20075332

BIX 02189

Tocris Bioscience, part of Bio-Techne | Catalog # 4842

Key Product Details

Biological Activity for BIX 02189

Technical Data for BIX 02189

Solubility for BIX 02189

Dilution Calculator

Reconstitution Calculator

References for BIX 02189

Product Documents for BIX 02189

COA

Certificate of Analysis

SDS

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