BMS 191011

Name: BMS 191011
Brand: Tocris Bioscience
SKU: 2665
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2665

(1)

Citations (13)

COA / SDS

Potent KCa1.1 (BK) channel opener

Key Product Details

Description:	Potent K_Ca1.1 (BK) channel opener
Chemical Name:	3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	370.71

View Full Technical Details for BMS 191011

Technical Data
Citations / Reviews (1)

Biological Activity for BMS 191011

BMS 191011 is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel, K_Ca1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Compound Libraries for BMS 191011

BMS 191011 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 191011

M. Wt	370.71
Formula	C₁₆H₁₀ClF₃N₂O₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	202821-81-6
PubChem ID	10474339
InChi Key	QKOWACXSXTXRKA-UHFFFAOYSA-N
Smiles	OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 191011

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	37.07	100

Preparing Stock Solutions for BMS 191011

The following data is based on the product molecular weight 370.71.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.70 mL	13.49 mL	26.98 mL
5 mM	0.54 mL	2.70 mL	5.40 mL
10 mM	0.27 mL	1.35 mL	2.70 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for BMS 191011

References are publications that support the biological activity of the product.

Hewawasam Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts.
Romine 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca²⁺-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem. 2007 PMID: 17266205