BMS 191011

Name: BMS 191011
Brand: Tocris Bioscience
SKU: 2665

Tocris Bioscience, part of Bio-Techne | Catalog # 2665

(1)

Citations (13)

COA / SDS

Potent KCa1.1 (BK) channel opener

Key Product Details

Chemical Name:	3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
Purity:	≥98%
Molecular Weight:	370.71 kDa

View Full Technical Details for BMS 191011

Technical Data
Citations / Reviews (1)

Biological Activity for BMS 191011

BMS 191011 is a potent BK_Ca channel opener (large-conductance Ca²⁺-activated potassium channel, K_Ca1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Technical Data for BMS 191011

M. Wt	370.71 kDa
Formula	C₁₆H₁₀ClF₃N₂O₃
Storage	Store at RT
Purity	≥98%
CAS Number	202821-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 191011

Solubility

Soluble Soluble to 100 mM in DMSO

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for BMS 191011

References are publications that support the biological activity of the product.

Romine et al. 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca²⁺-activated potassium (Maki-K) channels, identification, solubility, and SAR. J.Med.Chem., 2007;50:528 PMID: 17266205
Hewawasam et al. Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection. Bioorg.Med.Chem.Letts., 2003;13:1695