BMS 195614

Name: BMS 195614
Brand: Tocris Bioscience
SKU: 3660

Tocris Bioscience, part of Bio-Techne | Catalog # 3660

Citations (27)

COA / SDS

Selective RARα antagonist

Key Product Details

Description:	Selective RARα antagonist
Alternative Names:	BMS614
Chemical Name:	4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	448.51

View Full Technical Details for BMS 195614

Technical Data
Citations

Biological Activity for BMS 195614

BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (K_i = 2.5 nM). Displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Antagonizes agonist-induced coactivator (CoA) recruitment.

Technical Data for BMS 195614

M. Wt	448.51
Formula	C₂₉H₂₄N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	182135-66-6
PubChem ID	445091
InChi Key	WGLMBRZXZDAQHP-UHFFFAOYSA-N
Smiles	O=C(NC4=CC=C(C(O)=O)C=C4)C3=CC1=C(C=C3)C(C)(C)CC=C1C2=CN=C(C=CC=C5)C5=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 195614

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.21	25

Preparing Stock Solutions for BMS 195614

The following data is based on the product molecular weight 448.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.92 mL	44.59 mL	89.18 mL
1.25 mM	1.78 mL	8.92 mL	17.84 mL
2.5 mM	0.89 mL	4.46 mL	8.92 mL
12.5 mM	0.18 mL	0.89 mL	1.78 mL

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References for BMS 195614

References are publications that support the biological activity of the product.

Germain Differential action on coregulator interaction defines retinoid agonists and neutral antagonists. Chem.Biol. 2009 PMID: 19477412
Schoenermark Retinoid-mediated suppression of tumor invasion and matrix metalloproteinase synthesis. Ann.N.Y.Acad.Sci.
Gehin Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem.Biol. 1999 PMID: 10421757