BMS 309403

Name: BMS 309403
Brand: Tocris Bioscience
SKU: 5258

Tocris Bioscience, part of Bio-Techne | Catalog # 5258

Citations (12)

COA / SDS

Potent and selective FABP4 inhibitor

Key Product Details

Description:	Potent and selective FABP4 inhibitor
Chemical Name:	2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	474.55

View Full Technical Details for BMS 309403

Technical Data
Citations

Biological Activity for BMS 309403

BMS 309403 is a potent and selective fatty acid binding protein 4, adipocyte (FABP4) inhibitor (K_i values are <2, 250 and 350 nM for FABP4, FABP3 and FABP5 respectively). Decreases fatty acid uptake in adipocytes in vitro and reduces atherosclerotic lesion area in a mouse model of atherosclerosis. Reduces blood glucose levels and increases insulin sensitivity in a mouse model of obesity. Orally active.

Compound Libraries for BMS 309403

BMS 309403 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 309403

M. Wt	474.55
Formula	C₃₁H₂₆N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	300657-03-8
PubChem ID	16122583
InChi Key	SJRVJRYZAQYCEE-UHFFFAOYSA-N
Smiles	CCC1=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=NN1C2=CC=CC=C2C3=CC=CC(OCC(O)=O)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 309403

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	47.45	100

Preparing Stock Solutions for BMS 309403

The following data is based on the product molecular weight 474.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.07 mL
5 mM	0.42 mL	2.11 mL	4.21 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for BMS 309403

References are publications that support the biological activity of the product.

Sulsky Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg.Med.Chem.Lett. 2007 PMID: 17502136
Lin BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS ONE 2012 PMID: 22952994
Furuhashi Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 2007 PMID: 17554340