BMS 470539 dihydrochloride

Name: BMS 470539 dihydrochloride
Brand: Tocris Bioscience
SKU: 4053

Tocris Bioscience, part of Bio-Techne | Catalog # 4053

Citations (1)

COA / SDS

Potent, selective MC1 receptor agonist

Discontinued Product

4053 has been discontinued. View all Melanocortin Receptor Agonists products.

Key Product Details

Chemical Name:	1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride
Purity:	≥98%

View Full Technical Details for BMS 470539 dihydrochloride

Technical Data
Citations

Biological Activity for BMS 470539 dihydrochloride

BMS 470539 dihydrochloride is a potent, selective melanocortin MC₁ receptor agonist (IC₅₀ = 120 nM). Exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. Inhibits leukocyte trafficking.

Technical Data for BMS 470539 dihydrochloride

Formula	C₃₂H₄₁N₅O₄.2HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	2341796-82-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 470539 dihydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for BMS 470539 dihydrochloride

References are publications that support the biological activity of the product.

Kang A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice. J.Leukoc.Biol., 2006;80:897 PMID: 16888084
Herpin et al. Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J.Med.Chem., 2003;46:1123 PMID: 12646021
Leoni et al. The melanocortin MC1 receptor agonist BMS-470539 inhibits leukocyte trafficking in the inflamed vasculature. Br.J.Pharmacol., 2010;160:171 PMID: 20331604

BMS 470539 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4053

Key Product Details

Biological Activity for BMS 470539 dihydrochloride

Technical Data for BMS 470539 dihydrochloride

Solubility for BMS 470539 dihydrochloride

Dilution Calculator

Reconstitution Calculator

References for BMS 470539 dihydrochloride

Product Documents for BMS 470539 dihydrochloride

COA

Certificate of Analysis

SDS

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