BMS 566419

Name: BMS 566419
Brand: Tocris Bioscience
SKU: 5492

Tocris Bioscience, part of Bio-Techne | Catalog # 5492

COA / SDS

Inosine monophosphatase dehydrogenase (IMPDH) inhibitor

Key Product Details

Description:	Inosine monophosphatase dehydrogenase (IMPDH) inhibitor
Chemical Name:	N-[1-[6-(4-Ethyl-1-piperazinyl)-3-pyridinyl]-1-methylethyl]-2-fluoro-9,10-dihydro-9-oxo-3-acridinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	487.57

View Full Technical Details for BMS 566419

Technical Data
Citations

Biological Activity for BMS 566419

BMS 566419 is a potent inosine monophosphate dehydrogenase (IMPDH) inhibitor (IC₅₀ = 17 nM). Inhibits proliferation of human T-lymphoblasts and PBMCs in vitro. Reduces paw swelling in a rat adjuvant arthritis model. Orally available.

Technical Data for BMS 566419

M. Wt	487.57
Formula	C₂₈H₃₀FN₅O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	566161-24-8
PubChem ID	9913339
InChi Key	XEVJUIZOZCFECP-UHFFFAOYSA-N
Smiles	O=C2C3=C(C=C(C(NC(C)(C)C4=CC=C(N5CCN(CC)CC5)N=C4)=O)C(F)=C3)NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 566419

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. HCl	24.38	50
	DMSO	48.76	100

Preparing Stock Solutions for BMS 566419

The following data is based on the product molecular weight 487.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.25 mL	20.51 mL
5 mM	0.41 mL	2.05 mL	4.10 mL
10 mM	0.21 mL	1.03 mL	2.05 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

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References for BMS 566419

References are publications that support the biological activity of the product.

Watterson Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J.Med.Chem. 2007 PMID: 17585753