BMS 961

Name: BMS 961
Brand: Tocris Bioscience
SKU: 3410

Tocris Bioscience, part of Bio-Techne | Catalog # 3410

Citations (26)

COA / SDS

Selective RARγ agonist

Key Product Details

Description:	Selective RARγ agonist
Chemical Name:	3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Purity:	≥97% (HPLC)
Molecular Weight:	399.46

View Full Technical Details for BMS 961

Technical Data
Citations

Biological Activity for BMS 961

BMS 961 is a selective RARγ agonist (EC₅₀ values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Compound Libraries for BMS 961

BMS 961 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BMS 961

M. Wt	399.46
Formula	C₂₃H₂₆FNO₄
Storage	Store at +4°C
Purity	≥97% (HPLC)
CAS Number	185629-22-5
PubChem ID	2418
InChi Key	AANFHDFOMFRLLR-UHFFFAOYSA-N
Smiles	CC1(C)C2=C(C=CC(C(O)C(NC3=CC=C(C(O)=O)C=C3F)=O)=C2)C(C)(C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 961

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.95	100

Preparing Stock Solutions for BMS 961

The following data is based on the product molecular weight 399.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.52 mL	25.03 mL
5 mM	0.50 mL	2.50 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References for BMS 961

References are publications that support the biological activity of the product.

Taneja Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA
Klaholz Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci.
Abu-Abed Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem. 1998 PMID: 9442090