Bromosporine

Name: Bromosporine
Brand: Tocris Bioscience
SKU: 4758

Tocris Bioscience, part of Bio-Techne | Catalog # 4758

Citations (1)

COA / SDS

Broad spectrum bromodomain inhibitor

Key Product Details

Description:	Broad spectrum bromodomain inhibitor
Chemical Name:	N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	404.44

View Full Technical Details for Bromosporine

Technical Data
Citations

Biological Activity for Bromosporine

Bromosporine is a broad spectrum bromodomain inhibitor. Accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the Bromosporine probe summary on the SGC website.

Compound Libraries for Bromosporine

Bromosporine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Bromosporine

M. Wt	404.44
Formula	C₁₇H₂₀N₆O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1619994-69-2
PubChem ID	72943187
InChi Key	UYBRROMMFMPJAN-UHFFFAOYSA-N
Smiles	CC1=C(NS(=O)(C)=O)C=C(C3=NN2C(C(NC(OCC)=O)=C3)=NN=C2C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bromosporine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.44	100

Preparing Stock Solutions for Bromosporine

The following data is based on the product molecular weight 404.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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Reconstitution Calculator

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References for Bromosporine

References are publications that support the biological activity of the product.

Gallenkamp Bromodomains and their pharmacological inhibitors. ChemMedChem 2014 PMID: 24497428