Bryostatin 1

Name: Bryostatin 1
Brand: Tocris Bioscience
SKU: 2383
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2383

(1)

Citations (29)

COA / SDS

Protein kinase C activator

Key Product Details

Description:	Protein kinase C activator
Alternative Names:	NSC 339555
Chemical Name:	(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.1^3,7.1^11,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
Purity:	≥98% (HPLC)
Molecular Weight:	905.04

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Technical Data
Citations / Reviews (1)

Biological Activity for Bryostatin 1

Bryostatin 1 is a protein kinase C (PKC) activator that binds with high affinity (K_i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents. Restores hippocampal synapses and spatial learning and memory in an in vivo model of fragile X syndrome.

Technical Data for Bryostatin 1

M. Wt	905.04
Formula	C₄₇H₆₈O₁₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	83314-01-6
PubChem ID	5280757
InChi Key	MJQUEDHRCUIRLF-TVIXENOKSA-N
Smiles	O=C(C)O[C@H](C(C)2C)C[C@@H](C[C@@H](O)CC(O[C@@H]([C@H](O)C)C[C@@H](O4)C3)=O)O[C@@]2(O)C[C@H](C1)O[C@@H](/C=C/C(C)(C)[C@@]4(O)[C@@H](OC(/C=C/C=C/CCC)=O)/C3=C/C(OC)=O)C/C1=C\C(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Bryostatin 1

References are publications that support the biological activity of the product.

Sun Bryostatin-1 restores hippocampal synapses and spatial learning and memory in adult fragile X mice. J Pharmacol Exp Ther. 2014 PMID: 24659806
Sun and Alkon Bryostatin-1: pharmacology and therapeutic potential as a CNS drug. CNS Drug Rev. 2006 PMID: 16834754
Wender The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proc.Natl.Acad.Sci.USA 1998 PMID: 9618462
Lorenzo The catalytic domain of protein kinase Cδ confers protection from down-regulation induced by bryostatin 1. J.Biol.Chem. 1997 PMID: 9407126

Bryostatin 1

Tocris Bioscience, part of Bio-Techne | Catalog # 2383

Key Product Details

Biological Activity for Bryostatin 1

Technical Data for Bryostatin 1

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Bryostatin 1

Product Documents for Bryostatin 1

COA

Certificate of Analysis

SDS

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