BSJ-03-123

Name: BSJ-03-123
Brand: Tocris Bioscience
SKU: 6921

Tocris Bioscience, part of Bio-Techne | Catalog # 6921

Citations (2)

COA / SDS

Selective Cdk6 Degrader (PROTAC®)

Key Product Details

Description:	Selective Cdk6 Degrader (PROTAC^®)
Chemical Name:	N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	937.02

View Full Technical Details for BSJ-03-123

Technical Data
Citations

Biological Activity for BSJ-03-123

BSJ-03-123 is a selective Cdk6 Degrader (PROTAC^®) (DC₅₀ in sub 10 μM range). Displays no degradation of closely related Cdk4.

Negative control BSJ-Bump (Cat. No. 6922) and Cdk6 antibody validated for Western Blot also available: Catalog # NBP1-87262.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Technical Data for BSJ-03-123

M. Wt	937.02
Formula	C₄₇H₅₆N₁₀O₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2361493-16-3
PubChem ID	137628658
InChi Key	LUHCYAOYQIFNRN-UHFFFAOYSA-N
Smiles	O=C1N(C2=NC(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)CC4)=NC=C2C(C)=C1C(C)=O)C8CCCC8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BSJ-03-123

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	93.7	100

Preparing Stock Solutions for BSJ-03-123

The following data is based on the product molecular weight 937.02.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.07 mL	5.34 mL	10.67 mL
5 mM	0.21 mL	1.07 mL	2.13 mL
10 mM	0.11 mL	0.53 mL	1.07 mL
50 mM	0.02 mL	0.11 mL	0.21 mL

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References for BSJ-03-123

References are publications that support the biological activity of the product.

Brand Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 2019 PMID: 30595531